Cryo-EM is a cutting-edge, complementary technique that reduces development time and guesswork of lead compound design thanks to better conformational knowledge of ligand-target complexes, improving your rational design efforts at the atomic level.
It can be used for the structural analysis of protein complexes, on intractable targets, and in the generation of atomic models. Our Cryo-EM Applications brochure provides you with a range of examples on how cryo-EM is driving cutting-edge research. These include:
- TRPV5 ion channels
- Insulin-receptor binding
- Glycoprotein secreted by the Ebola virus
- GPCR membrane protein
- Tau filaments associated with Alzheimer’s disease
- β-galactosidase tetramers at atomic resolution
Additionally, an expansive list of structures (with resolutions) determined with cryo-EM is provided as a quick reference.