Analyze large, complex and flexible structures without crystallization.
Obtain structural information from mere nanocrystals of compound.
Acquire time-critical information for your increasingly challenging targets.
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Single-particle EM depends on the computational averaging of thousands of images of identical particles hence structural heterogeneity should be minimized through biochemical means to simplify structure determination.
Although the single particle analysis workflow can alleviate partial heterogeneity in the specimen via 3D classification procedures, biochemical purification of the sample material to obtain a solution of isolated target proteins is required.
Cryo-EM specimens are typically prepared using several microliters of protein solution at a concentration ranging between 50 nM and 5 μM, depending on the specimen, EM grids and conditions used.
Learn more about Biochemical sample preparation in the single particle analysis workflow.
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