High-resolution imaging of large proteins complexes

The history and future of cryo-EM

Most proteins that are of interest as drug targets are large, asymmetric and act in complexes. Existing analytical techniques are limited to a subset of possible protein analytes; in fact, only 1% of all structures in the Protein Data Bank (PDB) that were resolved by crystallography are complex structures composed of more than four chains. Cryo-EM enables high-resolution imaging of large protein complexes without crystallization, providing key information on drug targets and disease mechanisms.

In our Cryo-EM and the Future of Drug Discovery brochure, we provide an overview and historical perspective on the method as well as publication and adoption trends, clearly indicating the growing interest in this exciting technique.

Latest news in cryo-EM

In our Cryo-EM and the Future of Drug Discovery brochure, we provide an overview and historical perspective on the method as well as publication and adoption trends, clearly indicating the growing interest in this exciting technique.

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